Imolekyuli ye-Hyaluronic acid (HA) inenani elikhulu lamaqela e-hydroxyl kunye namanye amaqela e-polar, anokufunxa amanzi malunga nobunzima obuphindwe ka-1000 njengobunzima "be-molecular sponge". Idatha ibonisa ukuba i-HA inokufunxa ukufuma okuphezulu phantsi komswakama ophantsi (33%), kunye nokufunxa ukufuma okuphantsi phantsi komswakama ophezulu (75%). Le propati ikhethekileyo iyaziqhelanisa neemfuno zesikhumba ngamaxesha ahlukeneyo onyaka kunye neendawo ezahlukeneyo zokufuma, ngoko ke yaziwa njengeyona nto ifanelekileyo yokufumisa indalo. Kwiminyaka yakutshanje, ngokuphuculwa kwetekhnoloji yemveliso kunye nokusasazwa kwezicelo zokhathalelo lolusu lwe-HA, ezinye iinkampani ezintsha ziqalise ukuphonononga iindlela zokulungiselela amalaphu e-HA.

Ukugquma

Indlela yokubopha yindlela yokucubungula esebenzisa iarhente yokugqiba equlethe i-HA ukunyanga ilaphu ngokulibopha. Amanyathelo athile kukulifaka ilaphu kwisisombululo sokugqiba ixesha elithile uze ulikhuphe, uze ulidlulise ekucinezeleni nasekulomiseni ukuze ekugqibeleni lilungise i-HA kwilaphu. Izifundo zibonise ukuba ukongeza i-HA kwinkqubo yokugqiba amalaphu aknitwe nge-nylon warp akunampembelelo ingako kumbala kunye nokuqina kombala welaphu, kwaye ilaphu eliphathwe nge-HA linempembelelo ethile yokufumisa. Ukuba ilaphu eliknitwe licutshungulwa libe yi-fiber linear density engaphantsi kwe-0.13 dtex, amandla okubopha e-HA kunye nefayibha anokuphuculwa, kwaye amandla okugcina umswakama welaphu anokuthintelwa ngenxa yokuhlamba nezinye izinto. Ukongeza, amalungelo obunikazi amaninzi abonisa ukuba indlela yokubopha ingasetyenziselwa ukugqiba umqhaphu, isilika, imixube ye-nylon/spandex kunye nezinye izinto. Ukongezwa kwe-HA kwenza ilaphu lithambe kwaye likhululeke, kwaye linomsebenzi wokufumisa nokunyamekela ulusu.

Ukufakwa kwe-Microcapsulation

Indlela ye-microcapsule yindlela yokusonga i-HA kwii-microcapsules ngezinto ezenza ifilimu, uze emva koko ulungise ii-microcapsules kwiifayibha zelaphu. Xa ilaphu lidibana nolusu, ii-microcapsules ziyaqhuma emva kokungqubana nokucinezelwa, kwaye zikhuphe i-HA, zinika impembelelo yokhathalelo lolusu. I-HA yinto enyibilikayo emanzini, eya kulahleka kakhulu ngexesha lenkqubo yokuhlamba. Unyango lwe-microencapsulation luya kwandisa kakhulu ukugcinwa kwe-HA kwilaphu kwaye luphucule ukuqina kokusebenza kwelaphu. I-Beijing Jiershuang High-Tech Co., Ltd. yenze i-HA yaba yi-nano-microcapsules yaza yayisebenzisa kwilaphu, kwaye izinga lokubuyiselwa komswakama kwilaphu lafikelela ngaphezulu kwe-16%. UWu Xiuying walungisa i-microcapsule efumisayo equlethe i-HA, waza wayibeka kwi-polyester ebhityileyo kunye nelaphu elicocekileyo lekotoni ngokusebenzisa i-resin edibanisa ubushushu obuphantsi kunye netekhnoloji yokulungisa ubushushu obuphantsi ukuze kufunyanwe ukugcinwa komswakama okuhlala ixesha elide kwelaphu.

Indlela yokwaleka

Indlela yokugquma ibhekisa kwindlela yokwenza ifilimu equlethe i-HA kumphezulu welaphu, kunye nokufezekisa isiphumo sokhathalelo lolusu ngokuqhagamshelana ngokupheleleyo nelaphu nolusu ngexesha lenkqubo yokunxiba. Umzekelo, iteknoloji yokuzihlanganisa ye-electrostatic self-assembly isetyenziselwa ukufaka inkqubo yokuhlanganisa i-chitosan cation kunye nenkqubo yokuhlanganisa i-anion ye-HA kumphezulu wefayibha yelaphu lekotoni. Le ndlela ilula kakhulu, kodwa isiphumo selaphu lokhathalelo lolusu elilungisiweyo sinokulahleka emva kokuhlamba izihlandlo ezininzi.

Indlela yefayibha

Indlela yefayibha yindlela yokongeza i-HA kwinqanaba le-fiber polymerization okanye i-spinning dope, ize ijikelezise. Le ndlela yenza i-HA ingabikho kuphela kumphezulu wefayibha, kodwa ikwasasazwe ngokulinganayo ngaphakathi kwefayibha, ngokuqina okuhle. UMILAŠIUS R et al. basebenzise itekhnoloji ye-electrospinning ukusasaza i-HA ngendlela yamaconsi kwi-nanofibers. Uvavanyo lubonise ukuba i-HA ihlala nasemva kokuntywila emanzini ashushu angama-95 ℃. I-HA sisakhiwo se-polymer eside-chain, kwaye imeko-bume yokusabela enobudlova ngexesha lenkqubo yokujikeleza inokubangela umonakalo kwisakhiwo sayo se-molecular. Ke ngoko, abanye abaphandi baye bayilungisa kwangaphambili i-HA ukuyikhusela, njengokulungiselela i-HA kunye negolide kwii-nanoparticles, baze bayisasaze ngokufanayo. Phakathi kweefayibha ze-polyamide, iifayibha zelaphu zobuhle ezinokuqina okuphezulu kunye nokusebenza kakuhle zinokufunyanwa.